• Sign in
  • Communities
  • BillCam
  • About Us
  • Shop
0
DailyClout

Help fund independent journalism.

Donate
  • Sign In
  • Home
  • Opinion
    • Outspoken
    • The Drew Allen Show on DailyClout
    • Heart & Mind
    • Investigate Everything
    • Emerald & Naomi
    • Generation Rogue
    • The Liberty Lobbyist
    • The Shannon Joy Show on DailyClout
    • Man in America on DailyClout
    • The Sarah Westall Show on DailyClout
  • Submissions
  • Events
  • Our Story
  • Shop
  • Become a Member!
  • Donate

DailyClout Pfizer Documents Analysis

COVID mRNA Vaccine LINKED to Acute Myopericarditis

June 27, 2022 • by Can Li, State Key Laboratory of Emerging Infectious Diseases, et al. - National Library of Medicine
COVID mRNA Vaccine LINKED to Acute Myopericarditis

coronavirus

Background

Post-vaccination myopericarditis is reported after immunization with coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines. The effect of inadvertent intravenous injection of this vaccine on the heart is unknown.

Methods

We compared the clinical manifestations, histopathological changes, tissue mRNA expression, and serum levels of cytokine/chemokine and troponin in Balb/c mice at different time points after intravenous (IV) or intramuscular (IM) vaccine injection with normal saline (NS) control.

Results

Although significant weight loss and higher serum cytokine/chemokine levels were found in IM group at 1–2 days post-injection (dpi), only IV group developed histopathological changes of myopericarditis as evidenced by cardiomyocyte degeneration, apoptosis, and necrosis with adjacent inflammatory cell infiltration and calcific deposits on visceral pericardium, although evidence of coronary artery or other cardiac pathologies was absent. Serum troponin level was significantly higher in IV group. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike antigen expression by immunostaining was occasionally found in infiltrating immune cells of the heart or injection site, in cardiomyocytes and intracardiac vascular endothelial cells, but not skeletal myocytes. The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks and were markedly aggravated by a second IM- or IV-booster dose. Cardiac tissue mRNA expression of interleukin (IL)-1β, interferon (IFN)-β, IL-6, and tumor necrosis factor (TNF)-α increased significantly from 1 dpi to 2 dpi in the IV group but not the IM group, compatible with presence of myopericarditis in the IV group. Ballooning degeneration of hepatocytes was consistently found in the IV group. All other organs appeared normal.

Conclusions

This study provided in vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis. Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk.

Keywords: mouse model, SARS-CoV-2, mRNA vaccine, intravenous, COVID-19
View Full Report
Spread the Word

Subscribe to DailyClout so you never miss an update!

Spread the Word

  • Please support DailyClout.io. Our research, our uncompromising, fact-based journalism, our compelling opinion pieces and videos, our BillCam platform that lets you pass good bills and stop bad bills, and our lawsuits to preserve medical freedom and secure accountability for wrongdoers, have all helped to keep America and countries around the world safer and freer. We need your donations to keep fighting for you and your loved ones. We cannot do any of it without you and your generous support. Please give what you can as a one-time donation, or please, if you can, send us a monthly recurring donation. Please put resources behind the values you support, and that we do so much to help you defend.

    Thank you.

  • $0.00

adverse events Covid intravenous mouse model mrna myopericarditis rna sars vaccine
Previous StoryIs Losing “Roe” Actually A Feminist Outcome?
Next StoryCo-Founder of Donbass Insider Shares Shocking Truth on Russia-Ukraine Conflict

Leave your comment Cancel Reply

You must be logged in to post a comment.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

Recent Posts

  • Copy of Copy of Untitled Design (10)
    “HHS to Stop Recommending Routine Covid Shots for Children, Pregnant Women” Thursday, 15, May
  • Copy of Copy of Untitled Design (9)
    “Big Win: Court Rules Pfizer Can Be Sued for Deception” Thursday, 15, May
  • Copy of Copy of Untitled Design (8)
    “Wisconsin Judge Accused of Aiding Illegal Immigrant — Faces Federal Charges” Thursday, 15, May
  • Copy of Copy of Untitled Design (7)
    “Trump Signs $1.2 Trillion Economic Deal With Qatar” Thursday, 15, May
  • Copy of Copy of Untitled Design (6)
    “Court Slams EU Over Secret Vaccine Texts With Pfizer CEO” Wednesday, 14, May

Blog Archive

Subscribe to Our Free Newsletter

  • About Us
  • Get Involved
  • Become a Member
  • BillCam
  • Communities
  • Contact Us
  • Donate
  • Submissions
  • Substack
  • Privacy Policy
View Cart Checkout Continue Shopping
Do you really want to logout of DailyClout?
Yes

You are now leaving DailyClout...