Could Blood Light Chains Be a Key to Understanding Post-Vaccine Health Issues?

Medical researchers are taking a closer look at a blood test called the serum free light chain (sFLC) test, and in a recent paper, Dr. Robert Chandler highlights findings that could reshape how doctors monitor immune problems.

What Are Free Light Chains?
Our immune system makes antibodies to fight off infections. Antibodies are built from two types of protein “chains”: heavy chains and light chains. Normally, a small number of these light chains float freely in the blood. But when the immune system is overactive—or when certain cancers are present—these light chains can show abnormal patterns.

Why Does This Matter Now?
Traditionally, doctors have used markers like CRP or ESR to check for inflammation. Dr. Chandler’s research suggests that measuring free light chains is much more sensitive. This means sFLC tests could pick up on immune disturbances earlier and more reliably.

In his recent analysis of vaccine safety reports, Dr. Chandler noted that some people who experienced serious side effects after COVID-19 shots also had unusual sFLC results. These patterns varied—sometimes one type of light chain was high, sometimes both, and in rare cases one was suppressed while the other stayed normal. Such results may point to immune dysfunction or, in a subset of cases, early signs of plasma cell disorders like monoclonal gammopathy or multiple myeloma.

What Does the Research Show?

• Polyclonal responses (increases in both types of light chains) often pointed to general inflammation.

• Monoclonal responses (imbalances in the ratio between the two types) are more concerning, as they can be linked to blood cancers or pre-cancerous conditions.

• Some autopsy and biopsy studies have also found lingering spike protein and immune cell damage in tissues long after vaccination, raising questions about long-term immune stimulation.

Dr. Chandler stresses that the sample sizes are small and that VAERS (the U.S. vaccine injury reporting system) only captures a fraction of real cases. Still, his findings point toward the need for more systematic study.

What’s Next?
Dr. Chandler proposes a new concept called “CoVax Disease” to describe a group of overlapping conditions seen in some patients after COVID-19 vaccination—ranging from nerve issues and heart problems to unusual immune cell growths.

The big takeaway: measuring free light chains could give doctors a clearer picture of who is at risk, who needs closer monitoring, and how the immune system is really responding—not just to vaccines, but also to infections and chronic inflammation.

Read the full paper here: https://ijvtpr.com/index.php/IJVTPR/article/view/121/420